Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.

Sánchez, C · Galve-Roperh, I · Canova, C · Brachet, P · Guzmán, M
Published 1998-09-25
Journal FEBS letters
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delta9-Tetrahydrocannabinol (THC), the major active component of marijuana, induced apoptosis in C6.9 glioma cells, as determined by DNA fragmentation and loss of plasma membrane asymmetry. THC stimulated sphingomyelin hydrolysis in C6.9 glioma cells. THC and N-acetylsphingosine, a cell-permeable ceramide analog, induced apoptosis in several transformed neural cells but not in primary astrocytes or neurons. Although glioma C6.9 cells expressed the CBI cannabinoid receptor, neither THC-induced apoptosis nor THC-induced sphingomyelin breakdown were prevented by SR141716, a specific antagonist of that receptor. Results thus show that THC-induced apoptosis in glioma C6.9 cells may rely on a CBI receptor-independent stimulation of sphingomyelin breakdown.


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Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.
Sánchez, C · Galve-Roperh, I · Canova, C · Brachet, P · Guzmán, M
FEBS letters
Journal Article · Research Support, Non-U.S. Gov't

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This is Version 6 (restored from Version 1) of this record. Anonymous user (IP: added this version on March 13, 2015. It is an edited version of the original data import from MEDLINE®/PubMed®. View changes to the previous version or view the complete version history.