Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.

Author
Sánchez, C · Galve-Roperh, I · Canova, C · Brachet, P · Guzmán, M
Published 1998-09-25
Journal FEBS letters
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Abstract

delta9-Tetrahydrocannabinol (THC), the major active component of marijuana, induced apoptosis in C6.9 glioma cells, as determined by DNA fragmentation and loss of plasma membrane asymmetry. THC stimulated sphingomyelin hydrolysis in C6.9 glioma cells. THC and N-acetylsphingosine, a cell-permeable ceramide analog, induced apoptosis in several transformed neural cells but not in primary astrocytes or neurons. Although glioma C6.9 cells expressed the CBI cannabinoid receptor, neither THC-induced apoptosis nor THC-induced sphingomyelin breakdown were prevented by SR141716, a specific antagonist of that receptor. Results thus show that THC-induced apoptosis in glioma C6.9 cells may rely on a CBI receptor-independent stimulation of sphingomyelin breakdown.

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Details

Title
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.
Author
Sánchez, C · Galve-Roperh, I · Canova, C · Brachet, P · Guzmán, M
Published
1998-09-25
Year
1998
Journal
FEBS letters
Type
Research Article ·
Language
eng
PMID
9771884
Keywords
Apoptosis · Drug Effects · Glioma · Drug Therapy · Receptors, Drug · Sphingomyelins · Metabolism · Tetrahydrocannabinol · Pharmacology · Cells

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