The characteristics of relapse in adult-onset minimal-change nephrotic syndrome

Author
Takei, Takashi · Koike, Minako · Suzuki, Koichi · Shirota, Satsuki · Itabashi, Mitsuyo · Ohtsubo, Shigeru · Sugiura, Hidekazu · Suzuki, Keiko · Kojima, Chiari · Takahashi, Masaki · Ino, Jun · Ogawa, Tetsuya · Uchida, Keiko · Tsuchiya, Ken · Yumura, Wako · Nitta, Kosaku
Published September 2007
Journal Clinical and Experimental Nephrology
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Abstract

Although minimal-change nephrotic syndrome (MCNS) is highly steroid-responsive, the frequency of relapses in some patients is high, necessitating the administration of repeated courses of prednisolone in high doses. It is, therefore, necessary to identify factors that can predict this increased risk of relapse in some patients in order to establish useful treatment methods to reduce the risk.

To clarify the factors that might increase the risk of relapses, the data of 82 Japanese adult patients with MCNS receiving treatment at our department were analyzed retrospectively. Of the total, 55 patients (67.1%) experienced relapse after showing an initial response. We divided the patients into two groups; namely, the nonrelapse group (n = 27) and the relapse group (n = 55), and compared the clinico-pathophysiological characteristics between the two groups.

Significantly increased serum immunoglobulin E (IgE) levels (P = 0.0002) and increased frequency of steroid side effects were observed in the relapse group as compared to the nonrelapse group.

To develop effective therapeutic modalities, it is important to have a thorough understanding of the clinico-pathophysiological characteristics of MCNS patients showing relapse.

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Details

Title
The characteristics of relapse in adult-onset minimal-change nephrotic syndrome
Author
Takei, Takashi · Koike, Minako · Suzuki, Koichi · Shirota, Satsuki · Itabashi, Mitsuyo · Ohtsubo, Shigeru · Sugiura, Hidekazu · Suzuki, Keiko · Kojima, Chiari · Takahashi, Masaki · Ino, Jun · Ogawa, Tetsuya · Uchida, Keiko · Tsuchiya, Ken · Yumura, Wako · Nitta, Kosaku
Year
2007
Journal
Clinical and Experimental Nephrology
Document Type
Research article
Language*
eng
Subjects
Minimal-change Nephrotic Syndrome (MCNS) · Relapse · Immunoglobulin E (IgE) · Steroid Side Effects

Fields edited by Q-Sensei or Q-Sensei's users are marked with an asterisk (*).
This is Version 3 of this record. Q-Sensei Corp. added this version on November 3, 2009. It is an edited version of the original data import from IngentaConnect.com. View changes to the previous version or view the complete version history.