Naturally derived biofunctional nanofibrous scaffold for skin tissue regeneration.

Author
Dev, V R Giri
Published online 2014-04-24
Journal International journal of biological macromolecules
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Abstract

Significant wound healing activity of Aloe vera (AV) and higher elastic strength of Silk fibroin (SF) along with mammalian cell compatibility makes AV and SF an attractive material for tissue engineering. The purpose of the present work was to combine their unique properties, with the advantage of electrospinning to prepare a hybrid transdermal biomaterial for dermal substitutes. The physico-chemical characterization of the developed scaffold showed finer morphology expressing amino and esteric groups with improved hydrophilic properties and favorable tensile strain of 116% desirable for skin tissue engineering. Their biological response showed favorable fibroblast proliferation compared to control which almost increased linearly by (p<0.01) 34.68% on day 3, (p<0.01) 19.13% on day 6, and (p<0.001) 97.86% on day 9 with higher expression of CMFDA, collagen and F-actin proteins. The obtained results prove that the nanofibrous scaffold with synergistic property of AV and SF would be a potential biomaterial for skin tissue regeneration.

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Details

Title
Naturally derived biofunctional nanofibrous scaffold for skin tissue regeneration.
Author*
Dev, V R Giri
Published online
2014-04-24
Published
2014-07
Year
2014
Journal
International journal of biological macromolecules
Type
Research Article ·
Language
eng
PMID
24768969
Keywords
Biocompatible Materials · Pharmacology · Nanofibers · Chemistry · Regeneration · Drug Effects · Skin · Tissue Engineering · Methods · Tissue Scaffolds · Tissues

Fields edited by Q-Sensei or Q-Sensei's users are marked with an asterisk (*).
This is Version 6 of this record. Anonymous user (IP:178.62.238.64) added this version on May 18, 2017. It is an edited version of the original data import from MEDLINE®/PubMed®. View changes to the previous version or view the complete version history.