Cyclophilin A: potential functions and therapeutic target for human cancer.

Author
Obchoei, Sumalee · Wongkham, Sopit · Wongkham, Chaisiri · Li, Min · Yao, Qizhi · Chen, Changyi
Published 2009-11
Journal Medical science monitor : international medical journal of experimental and clinical research
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Abstract

Cyclophilin A (CypA) is a cytosolic binding protein of the immunosuppressive drug cyclosporin A. CypA has an activity of peptidylprolyl cis-trans isomerase, which may play important roles in protein folding, trafficking, assembly, immune-modulator and cell signaling. Secreted form of CypA can act as growth factors in several cell types. On the other hand, CypA also involves in pathogenesis in several diseases including viral infection, cardiovascular disease and cancer. For example, CypA protein displays an unusually high expression in several cancer types and correlates with poor outcome of the patients. In this review, we have focused on the recently available clinical data of altered CypA expression in various tumor tissues and cell lines and discussed contributions and potential molecular mechanisms of CypA to tumor progression and clinical association. CypA could promote cancer cell proliferation, anti-apoptosis, cell migration/invasion and drug resistant in various cancer cell types. The mechanism by which CypA contributes to cancer progression appears to involve a complex interplay of proteins and pathways including membrane receptor for CypA, CD147, and CypA binding partners inside the cells. CypA could be used as a molecular target for cancer therapy.

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Details

Title
Cyclophilin A: potential functions and therapeutic target for human cancer.
Author*
Obchoei, Sumalee · Wongkham, Sopit · Wongkham, Chaisiri · Li, Min · Yao, Qizhi · Chen, Changyi
Published
2009-11
Year
2009
Journal
Medical science monitor : international medical journal of experimental and clinical research
Type
Research Article · Review
Language
eng
PMID
19865066
Keywords
Cyclophilin A · Metabolism · Neoplasms · Therapy · Cyclophilins · Therapeutics · Humans · Cancer

Fields edited by Q-Sensei or Q-Sensei's users are marked with an asterisk (*).
This is Version 6 of this record. Anonymous user (IP:114.128.134.15) added this version on March 22, 2010. It is an edited version of the original data import from MEDLINE®/PubMed®. View changes to the previous version or view the complete version history.