[Long-term survival analysis in 89 adult patients with acute myeloid leukemia of fusion gene aml1/eto positive].

Author
Fang, Yan-Hong · Liu, Hong-Xing · Tong, Chun-Rong
Published 2009-06
Journal Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology
  See all Details

Abstract

This study was aimed to investigate various factors influencing long-term survival in adult AML patients with fusion gene aml1/eto positive. A single institutional retrospective study with long-term follow-up was performed to better define the prognostic factors for AML patients with aml1/eto positive. Newly diagnosed 89 adult AML patients with aml1/eto positive were followed up for 1 to 42 months (median 24 months) from January 2004 to July 2008. Univariate and multivariate analysis of potential factors influencing survival and prognosis were carried out by using Log-Rank and Cox regression method, including sex, age, initial WBC counts, extramedullary leukemic disease, central nervous system leukemia (CNSL), chromosome aberrations, immunophenotype, first induction regimen, chemotherapy course to complete remission (CR), time from induction therapy to CR, negative or positive rate of aml1/eto and allogeneic hematopoietic stem cell transplantation and so on. The results showed that the estimated 5-year overall survival (OS) and relapse-free survival (RFS) were (50.0 +/- 2.3)% and (47.0 +/- 1.9)% respectively in follow-up of 89 patients for 1 - 42 months (mean 24 months). Univariate analysis revealed that initial WBC counts, CNSL, chemotherapy course to CR, time from induction therapy to CR, persistent negative in remission and allogeneic hematopoietic stem cell transplantation were important prognostic factors for long-term surviva1. Multivariate study demonstrated that initial WBC counts, CNSL, CD56 positive, negative or positive rate of aml1/eto, time from induction therapy to CR, persistent negative result of RT-PCR assay in remission and allogeneic hematopoietic stem cell transplantation were all critical factors in relation to OS and RFS. It is concluded that Chinese adult AML patients with fusion gene aml1/eto positive have some different characteristics as compared with patients from other countries, a relatively poor outcome is observed in patients, HSCT should be recommended to adult AML patients.

Reviews

Write Review

Saving... Saving... Cancel Save Cancel

Details

Title
[Long-term survival analysis in 89 adult patients with acute myeloid leukemia of fusion gene aml1/eto positive].
Author
Fang, Yan-Hong · Liu, Hong-Xing · Tong, Chun-Rong
Published
2009-06
Year
2009
Journal
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology
Type
Abstract · Research Article
Language
chi
PMID
19549401
Keywords*
Core Binding Factor Alpha 2 Subunit · Genetics · Leukemia, Myeloid, Acute · Mortality · Oncogene Proteins, Fusion · Survival Analysis · Patients · Adult · Leukemia, Myeloid · Survival · Genes · Leukemia

Fields edited by Q-Sensei or Q-Sensei's users are marked with an asterisk (*).
This is Version 7 of this record. Q-Sensei Corp. added this version on January 10, 2012. It is an edited version of the original data import from MEDLINE®/PubMed®. View changes to the previous version or view the complete version history.