Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo.

Author
Marbacher, Serge · Neuschmelting, Volker · Graupner, Thilo · Jakob, Stephan M · Fandino, Javier
Published online 2008-01-24
Journal Intensive care medicine
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Abstract

OBJECTIVE: Intrathecal bolus administration of nitric oxide donors and calcium channel antagonists has been proposed to reduce cerebral vasospasm (CVS) in animal subarachnoid hemorrhage (SAH) models. Intrathecal continuous administration of these substances for CVS prevention has not been extensively evaluated. This study compared the efficacy of continuous intrathecal infusions of the NO donor glyceroltrinitrate and nimodipine in preventing delayed CVS associated with SAH in an animal model in vivo. METHODS: New Zealand White rabbits were randomly assigned to six groups: no SAH/NaCl, no SAH/NO, no SAH/nimodipine, SAH/NaCl, SAH/NO, or SAH/nimodipine. Glyceroltrinitrate (GTN) at 0.5 microg/microl (0.5 microl/h) or nimodipine at 0.2 microg/microl (10 microl/h) or NaCl was continuously infused into the cisterna magna via an Alzet osmotic pump from day 0 to day 5 after injection of 1.0 ml autologous blood. The magnitude of spasm in the basilar artery was determined by comparison of pre- and posttreatment angiography and was calculated as proportional change in intraluminal diameter based on automatic measurements. RESULTS: A total of 55 experiments and 110 angiograms were performed. SAH was associated with vasoconstriction of the basilar artery (SAH/NaCl group 19.85+/-2.94%). Continuous intrathecal injection of GTN and nimodipine prevented SAH-induced CVS. There was significant prevention of CVS in animals treated with GTN (SAH/NO group 5.93+/-5.2%, n=11) and nimodipine (SAH/nimodipine group: 0.55+/-2.66%, n=9). There was no significant difference between the treatment groups and controls in prevention of CVS. CONCLUSIONS: This study demonstrates that prophylactic continuous intrathecal administration of either GTN or nimodipine equally prevents SAH-associated CVS in an animal model.

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Details

Title
Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo.
Author*
Marbacher, Serge · Neuschmelting, Volker · Graupner, Thilo · Jakob, Stephan M · Fandino, Javier
Published online
2008-01-24
Published
2008-05
Year
2008
Journal*
Intensive care medicine
Type*
Study · Research Article ·
Language*
eng
PMID
18214428
Keywords*
Nimodipine · Administration & Dosage · Nitroglycerin · Subarachnoid Hemorrhage · Complications · Vasodilator Agents · Vasospasm, Intracranial · Prevention & Control · Cerebral Vasospasm

Fields edited by Q-Sensei or Q-Sensei's users are marked with an asterisk (*).
This is Version 19 (restored from Version 13) of this record. max_richter added this version on May 10, 2010. It is an edited version of the original data import from MEDLINE®/PubMed®. View changes to the previous version or view the complete version history.