Nutritional aspects in patients with non-alcoholic steatohepatitis (NASH).

Author
Capristo, E · Miele, L · Forgione, A · Vero, V · Farnetti, S · Mingrone, G · Greco, A V · Gasbarrini, G · Grieco, A
Published 2005 Sep-Oct
Journal European review for medical and pharmacological sciences
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Abstract

BACKGROUND AND OBJECTIVES: Metabolic alterations are a common feature in patients affected by non-alcoholic steato-hepatitis (NASH). A strong correlation exists between overweight, in particular visceral fat accumulation, and prevalence of NASH, especially in men. Thus, diet-induced weight loss represents a fundamental tool in disease management of these patients. The aim of the present study was to evaluate body composition and nutrient utilisation in patients with NASH, comparing them with patients affected by chronic hepatitis related to hepatitis C virus (HCV) infection and with healthy subjects. MATERIALS AND METHODS: Twenty male outpatients with NASH (age: 41 +/- 11 yr; BMI: 26.2 +/- 2.1 kg/m2) and 14 HCV male patients (age 44.6 +/- 13 yr; BMI: 24.8 +/- 2.8 kg/m2) were enrolled in the study. A group of 20 healthy male subjects (age: 39 +/- 10 yr; BMI: 23.3 +/- 1.1 kg/m2) were studied as controls. Body composition was assessed by anthropometry and dual-energy X-ray absorptiometry; resting metabolic rate and nutrient oxidation by indirect calorimetry. A 7-day food diary was collected. The main biochemical parameters were measured using standardised laboratory techniques. RESULTS: Body weight was higher in NASH patients with respect to HCV patients and control subjects (respectively 75.2 +/- 8.9 vs 68.5 +/- 9.4 and vs 67.0 +/- 8.0 kg; P < 0.01) and this was essentially due to fat mass increase. Fat-free mass reduction was found in HCV patients with respect to both NASH and control subjects. Patients with NASH had a significantly higher waist circumference (P < 0.01) and a lower resting metabolic rate (RMR) with respect to HCV and control subjects. Energy intake was significantly higher in NASH patients (P < 0.01) compared to the other two groups. CONCLUSIONS: NASH patients showed an increase in body weight, fat mass and visceral fat accumulation with respect to HCV and control subjects. The reduction in RMR, coupled with increase energy intake may explain the body composition alterations found in these patients.

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Details

Title
Nutritional aspects in patients with non-alcoholic steatohepatitis (NASH).
Author
Capristo, E · Miele, L · Forgione, A · Vero, V · Farnetti, S · Mingrone, G · Greco, A V · Gasbarrini, G · Grieco, A
Published
2005 Sep-Oct
Year
2005
Journal
European review for medical and pharmacological sciences
Type
Study · Research Article
Language
eng
PMID
16231587
Keywords
Fatty Liver · Metabolism · Hepatitis C, Chronic · Patients

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This is Version 3 of this record. Q-Sensei Corp. added this version on January 3, 2010. It is an edited version of the original data import from MEDLINE®/PubMed®. View changes to the previous version or view the complete version history.